MW: 150,803.64 Da
No. of AA: 1291
Abs 0.1% (g/L): 1.313
pI: 5.23
NCBI ID: WP_012291519.1
UniprotKB: B1INP5
Strains: CN 5009, BL 143, ATCC 2743, 4301B, 5009, Okra, BL 150, Colworth BL147, CN 7242, Colworth BL86, NCTC 7273, NCIB 4301, CDC 15044, FT 239, CN 5009 (2), BL 143 (2), NCTC 7273 (2), DFPST0017, DFPST003, DFPST0006, DFPST005, DFPST002, CCUG 7969, Okra_B UMBAC_00010
Associated Proteins: NTNH/B1 (E014).
Notes:
Genetic diversity among Botulinum Neurotoxin-producing clostridial strains.
Hill KK, Smith TJ, Helma CH, Ticknor LO, Foley BT, Svensson RT, Brown JL, Johnson EA, Smith LA, Okinaka RT, Jackson PJ, Marks JD. (2007). J Bacteriol.
DOI: 10.1128/JB.01180-06 PMID: 17114256
Molecular cloning of the Clostridium botulinum structural gene encoding the type B neurotoxin and determination of its entire nucleotide sequence.
Whelan SM, Elmore MJ, Bodsworth NJ, Brehm JK, Atkinson T, Minton NP. (1992). Appl Environ Microbiol.
DOI: PMID: 1514783
Structure of dual receptor binding to botulinum neurotoxin B.
Berntsson RP, Peng L, Dong M, Stenmark P. (2013). Nat Commun
DOI: 10.1038/ncomms3058 PMID: 23807078
Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems.
Elliott M, Maignel J, Liu SM, Favre-Guilmard C, Mir I, Farrow P, Hornby F, Marlin S, Palan S, Beard M, Krupp J. (2017). PLoS ONE
DOI: 10.1371/journal.pone.0185628 PMID: 28982136
Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors.
Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M. (2017). Nat Commun
DOI: 10.1038/s41467-017-00064-y PMID: 28674381
A Cell Line for Detection of Botulinum Neurotoxin Type B.
Rust A, Doran C, Hart R, Binz T, Stickings P, Sesardic D, Peden AA, Davletov B. (2017). Front Pharmacol
DOI: 10.3389/fphar.2017.00796 PMID: 29170639
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J. (2019). Sci Adv
DOI: 10.1126/sciadv.aau7196 PMID: 30746458
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B.
Flores A, Ramirez-Franco J, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf F, Sangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque C, El Far O. (2019). Proc. Natl. Acad. Sci. U.S.A.
DOI: 201908051 PMID: 31431523
Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors.
Davies JR, Masuyer G, Stenmark P. (2020). Toxins (Basel)
DOI: E603 PMID: 32957706