2020
Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors.
Davies JR, Masuyer G, Stenmark P. (2020). Toxins (Basel) PMID: 32957706. DOI: E603 BBID: D145 AE36
2019
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J. (2019). Sci Adv PMID: 30746458. DOI: 10.1126/sciadv.aau7196 BBID: D145
Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons.
Joussain C, Le Coz O, Pichugin A, Marconi P, Lim F, Sicurella M, Salonia A, Montorsi F, Wandosell F, Foster K, Giuliano F, Epstein AL, Aranda Muñoz A. (2019). Toxins (Basel) PMID: 30791373. DOI: 10.3390/toxins11020123 BBID: D356 0179 C378 CE39 AD49 DF19
Botulinum neurotoxin serotype D - a potential treatment alternative for BoNT/A and B non-responding patients
Kutschenkoa et al. (Accepted Manuscript, In Press) (2019). Clinical Neurophysiology PMID: 30871800. DOI: 10.1016/j.clinph.2019.02.007 BBID: CE39
Crystal structure of the catalytic domain of the Weissela oryzae botulinum-like toxin.
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P. (2019). FEBS Lett. PMID: 31111466. DOI: 10.1002/1873-3468.13446 BBID: F013
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B.
Flores A, Ramirez-Franco J, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf F, Sangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque C, El Far O. (2019). Proc. Natl. Acad. Sci. U.S.A. PMID: 31431523. DOI: 201908051 BBID: D145
The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA.
Fan Y, Barash JR, Conrad F, Lou J, Tam C, Cheng LW, Arnon SS, Marks JD. (2019). Toxins (Basel) PMID: 31877649. DOI: 10.3390/toxins12010009 BBID: C045
2018
Identification of a novel botulinum neurotoxin gene cluster in Enterococcus.
Brunt J, Carter AT, Stringer SC, Peck MW. (2018). FEBS Lett. PMID: 29323697. DOI: 10.1002/1873-3468.12969 BBID: DE18
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.
Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. (2018). Cell Host Microbe PMID: 29396040. DOI: 10.1016/j.chom.2017.12.018 BBID: DE18
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.
Stern D, Weisemann J, Le Blanc A, von Berg L, Mahrhold S, Piesker J, Laue M, Luppa PB, Dorner MB, Dorner BG, Rummel A. (2018). PLoS Pathog. PMID: 29718991. DOI: 10.1371/journal.ppat.1007048 BBID: AEF5 ACD0 C345
The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes.
Pellett S, Bradshaw M, Tepp WH, Pier CL, Whitemarsh RCM, Chen C, Barbieri JT, Johnson EA. (2018). MBio PMID: 29588398. DOI: 10.1128/mBio.00089-18 BBID: D356 AC46
High resolution crystal structures of the receptor-binding domain of neurotoxin serotypes A and FA.
Davies JR, Hackett GS, Liu SM, Acharya KR. (2018). PeerJ PMID: 29576992. DOI: 10.7717/peerj.4552 BBID: D356 C045
Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Masuyer G, Zhang S, Barkho S, Shen Y, Henriksson L, Košenina S, Dong M, Stenmark P. (2018). Sci Rep PMID: 29540745. DOI: 10.1038/s41598-018-22842-4 BBID: F347
Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H.
Hackett G, Moore K, Burgin D, Hornby F, Gray B, Elliott M, Mir I, Beard M. (2018). Toxins (Basel) PMID: 29751611. DOI: 10.3390/toxins10050195 BBID: C045 C045
Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P. (2018). Toxins (Basel) PMID: 29649119. DOI: 10.3390/toxins10040153 BBID: CEF8
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁻K Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.
Sikorra S, Skiba M, Dorner MB, Weisemann J, Weil M, Valdezate S, Davletov B, Rummel A, Dorner BG, Binz T. (2018). Toxins (Basel) PMID: 30071628. DOI: 10.3390/toxins10080311 BBID: F268
Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.
Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R. (2018). Pathog Dis PMID: 29688327. DOI: 10.1093/femspd/fty044 BBID: C045
Comparison of efficacy and toxicity between botulinum toxin subtypes A1 and A2 in cynomolgus macaques.
Torii Y, Sasaki M, Shin MC, Akaike N, Kaji R. (2018). Toxicon PMID: 30193802. DOI: 10.1016/j.toxicon.2018.08.017 BBID: CEF8 D356
Isolation and Characterization of the Novel Botulinum Neurotoxin A Subtype 6.
Moritz MS, Tepp WH, Bradshaw M, Johnson EA, Pellett S. (2018). mSphere PMID: 30355669. DOI: 10.1128/mSphere.00466-18 BBID: AC09
A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.
Lam KH, Guo Z, Krez N, Matsui T, Perry K, Weisemann J, Rummel A, Bowen ME, Jin R. (2018). Nat Commun PMID: 30560862. DOI: 10.1038/s41467-018-07789-4 BBID: ADF1
In Silico Mutagenesis: Decreasing the Immunogenicity of Botulinum Toxin Type A.
Evander Emeltan Tjoa S, Maria Vianney Y, Emantoko Dwi Putra S. (2018). J. Biomol. Struct. Dyn. PMID: 30558486. DOI: 10.1080/07391102.2018.1559100 BBID: D158
2017
Identification and characterization of a novel botulinum neurotoxin.
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martinez-Carranza M, Dong M, Stenmark P. (2017). Nat Commun. PMID: 28770820. DOI: 10.1038/ncomms14130 BBID: F347
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.
Yao G, Lam KH, Perry K, Weisemann J, Rummel A, Jin R. (2017). Toxins. PMID: 28282873. DOI: 10.3390/toxins9030093 BBID: C045
Substrate cleavage and duration of action of botulinum neurotoxin type FA ("H, HA").
Pellett S, Tepp WH, Lin G, Johnson EA. (2017). Toxicon. PMID: 29273248. DOI: 10.1016/j.toxicon.2017.12.048 BBID: C045
High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains.
Davies JR, Rees J, Liu SM, Acharya KR. (2017). J Struct Biol. PMID: 29288126. DOI: 10.1016/j.jsb.2017.12.010 BBID: AD28 AC46
Differentiating Botulinum Neurotoxin-Producing Clostridia with a Simple, Multiplex PCR Assay.
Williamson CHD, Vazquez AJ, Hill K, Smith TJ, Nottingham R, Stone NE, Sobek CJ, Cocking JH, Fernández RA, Caballero PA, Leiser OP, Keim P, Sahl JW. (2017). Appl. Environ. Microbiol. PMID: 28733282. DOI: 10.1128/AEM.00806-17 BBID:
Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.
Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong M. (2017). Nat Commun PMID: 29158482. DOI: 10.1038/s41467-017-01534-z BBID: C345 CE39 DF15
Characterization of the functional activity of botulinum neurotoxin subtype B6.
Kohda T, Nakamura K, Hosomi K, Torii Y, Kozaki S, Mukamoto M. (2017). Microbiol. Immunol. PMID: 28898517. DOI: 10.1111/1348-0421.12540 BBID: D036
The structure of the tetanus toxin reveals pH-mediated domain dynamics.
Masuyer G, Conrad J, Stenmark P. (2017). EMBO Rep. PMID: 28645943. DOI: 10.15252/embr.201744198 BBID: E139
Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems.
Elliott M, Maignel J, Liu SM, Favre-Guilmard C, Mir I, Farrow P, Hornby F, Marlin S, Palan S, Beard M, Krupp J. (2017). PLoS ONE PMID: 28982136. DOI: 10.1371/journal.pone.0185628 BBID: D145
Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.
Benoit RM, Schärer MA, Wieser MM, Li X, Frey D, Kammerer RA. (2017). Sci Rep PMID: 28252640. DOI: 10.1038/srep43588 BBID: CEF8
Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors.
Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M. (2017). Nat Commun PMID: 28674381. DOI: 10.1038/s41467-017-00064-y BBID: D145
Finished Whole-Genome Sequence of Producing Botulinum Neurotoxin Type G.
Halpin JL, Hill K, Johnson SL, Bruce DC, Shirey TB, Dykes JK, Lúquez C. (2017). Genome Announc PMID: 28546482. DOI: 10.1128/genomeA.00380-17 BBID: A128
A Cell Line for Detection of Botulinum Neurotoxin Type B.
Rust A, Doran C, Hart R, Binz T, Stickings P, Sesardic D, Peden AA, Davletov B. (2017). Front Pharmacol PMID: 29170639. DOI: 10.3389/fphar.2017.00796 BBID: D145
2016
The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain.
Zornetta I, Azarnia Tehran D, Arrigoni G, Anniballi F, Bano L, Leka O, Zanotti G, Binz T, Montecucco C. (2016). Sci Rep. PMID: 27443638. DOI: 10.1038/srep30257 BBID: F013
Evolution of Chromosomal Clostridium botulinum Type E Neurotoxin Gene Clusters: Evidence Provided by Their Rare Plasmid-Borne Counterparts.
Carter AT, Austin JW, Weedmark KA, Peck MW. (2016). Genome Biol Evol. PMID: 26936890. DOI: 10.1093/gbe/evw017 BBID: BD19
Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain.
Pellett S, Tepp WH, Bradshaw M, Kalb SR, Dykes JK, Lin G, Nawrocki EM, Pier CL, Barr JR, Maslanka SE, Johnson EA. (2016). mSphere. PMID: 27303710. DOI: 10.1128/mSphere.00100-15 BBID: C045
2015
First report of an infant botulism case due to Clostridium botulinum type Af.
de Jong LI, Fernandez RA, Pareja V, Giaroli G, Guidarelli SR, Dykes JK, Luquez C. (2015). J Clin Microbiol. PMID: 25502535. DOI: 10.1128/JCM.02894-14 BBID: 0689
Genomic characterization of Italian Clostridium botulinum group I strains.
Giordani F, Fillo S, Anselmo A, Palozzi AM, Fortunato A, Gentile B, Azarnia Tehran D, Ciammaruconi A, Spagnolo F, Pittiglio V, Anniballi F, Auricchio B, De Medici D, Lista F. (2015). Infect Genet Evol. PMID: 26341861. DOI: 10.1016/j.meegid.2015.08.042 BBID: CDE2 A129 F456 1269 D025
Whole-Genome Sequence of Clostridium botulinum A2B3 87, a Highly Virulent Strain Involved in a Fatal Case of Foodborne Botulism in Italy.
Giordani F, Fillo S, Anselmo A, Palozzi AM, Fortunato A, Gentile B, Pittiglio V, Spagnolo F, Anniballi F, Fiore A, Auricchio B, De Medici D, Lista F. (2015). Genome Announc. PMID: 25814616. DOI: 10.1128/genomeA.00237-15 BBID: D679
Genomic sequences of six botulinum neurotoxin-producing strains representing three clostridial species illustrate the mobility and diversity of botulinum neurotoxin genes.
Smith TJ, Hill KK, Xie G, Foley BT, Williamson CH, Foster JT, Johnson SL, Chertkov O, Teshima H, Gibbons HS, Johnsky LA, Karavis MA, Smith LA. (2015). Infect Genet Evol. PMID: 25489752. DOI: 10.1016/j.meegid.2014.12.002 BBID: BF04 2468 AE36 A128 B156
Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype.
Kull S, Schulz KM, Weisemann J, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG. (2015). PLoS One. PMID: 25658638. DOI: 10.1371/journal.pone.0116381 BBID: ABC6
An atypical outbreak of food-borne botulism due to Clostridium botulinum types B and E from ham.
Mazuet C, Sautereau J, Legeay C, Bouchier C, Bouvet P, Popoff MR. (2015). J Clin Microbiol. PMID: 25428161. DOI: 10.1128/JCM.02942-14 BBID: BCD1
Draft Genome Sequence of Clostridium botulinum Strain 277-00 Type B2.
Mazuet C, Bouchier C, Popoff MR. (2015). Genome Announc. PMID: 25838479. DOI: 10.1128/genomeA.00211-15 BBID: BF25
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy.
Fillo S, Giordani F, Anselmo A, Fortunato A, Palozzi AM, De Santis R, Ciammaruconi A, Spagnolo F, Anniballi F, Fiore A, Auricchio B, De Medici D, Lista F. (2015). Genome Announc PMID: 25838491. DOI: 10.1128/genomeA.00238-15 BBID: F078
Draft Genome Sequences of 17 French Clostridium botulinum Group III Strains.
Woudstra C, Le Maréchal C, Souillard R, Bayon-Auboyer MH, Mermoud I, Desoutter D, Fach P. (2015). Genome Announc PMID: 26430029. DOI: 10.1128/genomeA.01105-15 BBID: BD02
Botulinum neurotoxin homologs in non-Clostridium species.
Mansfield MJ, Adams JB, Doxey AC. (2015). FEBS Lett. PMID: 25541486. DOI: 10.1016/j.febslet.2014.12.018 BBID: F013 F013
Laboratory Investigation of the First Case of Botulism Caused by Clostridium butyricum Type E Toxin in the United States.
Dykes JK, Lúquez C, Raphael BH, McCroskey L, Maslanka SE. (2015). J. Clin. Microbiol. PMID: 26246485. DOI: 10.1128/JCM.01351-15 BBID: F145
Comparative characterization of botulinum neurotoxin subtypes F1 and F7 featuring differential substrate recognition and cleavage mechanisms.
Guo J, Chan EW, Chen S. (2015). Toxicon PMID: 26748154. DOI: 10.1016/j.toxicon.2015.12.020 BBID: F068 DF19
2014
Whole-genome single-nucleotide-polymorphism analysis for discrimination of Clostridium botulinum group I strains.
Gonzalez-Escalona N, Timme R, Raphael BH, Zink D, Sharma SK. (2014). Appl Environ Microbiol. PMID: 24463972. DOI: 10.1128/AEM.03934-13 BBID: BF04
Draft Genome Sequence of Weissella oryzae SG25T, Isolated from Fermented Rice Grains.
Tanizawa Y, Fujisawa T, Mochizuki T, Kaminuma E, Suzuki Y, Nakamura Y, Tohno M. (2014). Genome Announc. PMID: 25013139. DOI: 10.1128/genomeA.00667-14 BBID: F013
Molecular characterization of Clostridium botulinum isolates from foodborne outbreaks in Thailand, 2010.
Wangroongsarb P, Kohda T, Jittaprasartsin C, Suthivarakom K, Kamthalang T, Umeda K, Sawanpanyalert P, Kozaki S, Ikuta K. (2014). PLoS One. PMID: 24475015. DOI: 10.1371/journal.pone.0077792 BBID: E489 C678
Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type.
Gonzalez-Escalona N, Thirunavukkarasu N, Singh A, Toro M, Brown EW, Zink D, Rummel A, Sharma SK. (2014). Genome Announc. PMID: 25502671. DOI: 10.1128/genomeA.01275-14 BBID: C045 ABC8
Two novel toxin variants revealed by whole-genome sequencing of 175 Clostridium botulinum type E strains.
Weedmark KA, Lambert DL, Mabon P, Hayden KL, Urfano CJ, Leclair D, Van Domselaar G, Austin JW, Corbett CR. (2014). Appl Environ Microbiol. PMID: 25107978. DOI: 10.1128/AEM.01573-14 BBID: AC04 A379 DE59 CD15 D247 D247 B257
Three classes of plasmid (47-63 kb) carry the type B neurotoxin gene cluster of group II Clostridium botulinum.
Carter AT, Austin JW, Weedmark KA, Corbett C, Peck MW. (2014). Genome Biol Evol. PMID: 25079343. DOI: 10.1093/gbe/evu164 BBID: BCF6 ACD0
Genetic characterization and comparison of Clostridium botulinum isolates from botulism cases in Japan between 2006 and 2011.
Kenri T, Sekizuka T, Yamamoto A, Iwaki M, Komiya T, Hatakeyama T, Nakajima H, Takahashi M, Kuroda M, Shibayama K. (2014). Appl. Environ. Microbiol. PMID: 25192986. DOI: 10.1128/AEM.02134-14 BBID: AD02 D678 D036 AD34 C237
Plasmidome interchange between Clostridium botulinum, Clostridium novyi and Clostridium haemolyticum converts strains of independent lineages into distinctly different pathogens.
Skarin H, Segerman B. (2014). PLoS ONE PMID: 25254374. DOI: 10.1371/journal.pone.0107777 BBID: D068
Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.
Dover N, Barash JR, Burke JN, Hill KK, Detter JC, Arnon SS. (2014). PLoS ONE PMID: 24853378. DOI: 10.1371/journal.pone.0097983 BBID:
Genome Sequence of the Neurotoxigenic Clostridium butyricum Strain 5521.
Hassan KA, Elbourne LD, Tetu SG, Johnson EA, Paulsen IT. (2014). Genome Announc PMID: 24970833. DOI: 10.1128/genomeA.00632-14 BBID:
Genome of a chronic osteitis-causing Clostridium tetani.
Fournier PE, Levy PY, Million M, Croce O, Blanc-Tailleur C, Brouqui P, Raoult D. (2014). New Microbes New Infect PMID: 25356334. DOI: 10.1002/2052-2975.27 BBID: 0128
Persistence of botulinum neurotoxin a subtypes 1-5 in primary rat spinal cord cells.
Whitemarsh RC, Tepp WH, Johnson EA, Pellett S. (2014). PLoS ONE PMID: 24587301. DOI: 10.1371/journal.pone.0090252 BBID: D356 CEF8 AE56 0238
2013
Genome Sequence of the Group III Clostridium botulinum Strain Eklund-C.
Hassan KA, Tetu SG, Elbourne LD, Johnson EA, Paulsen IT. (2013). Genome Announc. PMID: 23516187. DOI: 10.1128/genomeA.00044-13 BBID: D014
Two simultaneous botulism outbreaks in Barcelona: Clostridium baratii and Clostridium botulinum.
Lafuente S, Nolla J, Valdezate S, Tortajada C, Vargas-Leguas H, Parron I, Sáez-Nieto JA, Portaña S, Carrasco G, Moguel E, Sabate S, Argelich R, Caylà JA. (2013). Epidemiol. Infect. PMID: 23158693. DOI: 10.1017/S0950268812002592 BBID: 5789
Improved detection methods by genetic and immunological techniques for botulinum C/D and D/C mosaic neurotoxins.
Nakamura K, Kohda T, Seto Y, Mukamoto M, Kozaki S. (2013). Vet. Microbiol. PMID: 23206412. DOI: 10.1016/j.vetmic.2012.11.009 BBID: BE01 E236 DEF6 0789 DF15
Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
Dover N, Barash JR, Hill KK, Davenport KW, Teshima H, Xie G, Arnon SS. (2013). PLoS ONE PMID: 23637798. DOI: 10.1371/journal.pone.0061205 BBID: CEF8 E567 CF09
Application of high-density DNA resequencing microarray for detection and characterization of botulinum neurotoxin-producing clostridia.
Vanhomwegen J, Berthet N, Mazuet C, Guigon G, Vallaeys T, Stamboliyska R, Dubois P, Kennedy GC, Cole ST, Caro V, Manuguerra JC, Popoff MR. (2013). PLoS ONE PMID: 23818983. DOI: 10.1371/journal.pone.0067510 BBID:
Structure of dual receptor binding to botulinum neurotoxin B.
Berntsson RP, Peng L, Dong M, Stenmark P. (2013). Nat Commun PMID: 23807078. DOI: 10.1038/ncomms3058 BBID: D145
Crystal structures of botulinum neurotoxin DC in complex with its protein receptors synaptotagmin I and II.
Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P. (2013). Structure PMID: 23932591. DOI: 10.1016/j.str.2013.06.026 BBID: C345
2012
Genetic diversity among Clostridium botulinum strains harboring bont/A2 and bont/A3 genes.
Luquez C, Raphael BH, Joseph LA, Meno SR, Fernandez RA, Maslanka SE. (2012). Appl Environ Microbiol. PMID: 23042179. DOI: 10.1128/AEM.02428-12 BBID: B237 AB06
Analysis of a unique Clostridium botulinum strain from the Southern hemisphere producing a novel type E botulinum neurotoxin subtype.
Raphael BH, Lautenschlager M, Kalb SR, de Jong LI, Frace M, Luquez C, Barr JR, Fernandez RA, Maslanka SE. (2012). BMC Microbiol. PMID: 23113872. DOI: 10.1186/1471-2180-12-245 BBID: BCF8 0138 BC79 B157 A357 AD49
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity.
Strotmeier J, Willjes G, Binz T, Rummel A. (2012). FEBS Lett. PMID: 22265973. DOI: 10.1016/j.febslet.2011.12.037 BBID: AEF5
De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics.
Kalb SR, Baudys J, Rees JC, Smith TJ, Smith LA, Helma CH, Hill K, Kull S, Kirchner S, Dorner MB, Dorner BG, Pirkle JL, Barr JR. (2012). Anal Bioanal Chem PMID: 22395449. DOI: 10.1007/s00216-012-5767-3 BBID: CEF0
Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT. (2012). J. Biol. Chem. PMID: 23027864. DOI: 10.1074/jbc.M112.404244 BBID: C378
Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5.
Kalb SR, Baudys J, Webb RP, Wright P, Smith TJ, Smith LA, Fernández R, Raphael BH, Maslanka SE, Pirkle JL, Barr JR. (2012). FEBS Lett. PMID: 22172278. DOI: 10.1016/j.febslet.2011.11.033 BBID: CF09
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.
Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M. (2012). J. Cell. Sci. PMID: 22454523. DOI: 10.1242/jcs.103564 BBID: C345
2011
Analysis of Clostridium botulinum serotype E strains by using multilocus sequence typing, amplified fragment length polymorphism, variable-number tandem-repeat analysis, and botulinum neurotoxin gene sequencing.
Macdonald TE, Helma CH, Shou Y, Valdez YE, Ticknor LO, Foley BT, Davis SW, Hannett GE, Kelly-Cirino CD, Barash JR, Arnon SS, Lindstrom M, Korkeala H, Smith LA, Smith TJ, Hill KK. (2011). Appl Environ Microbiol. PMID: 22003031. DOI: 10.1128/AEM.05155-11 BBID: BCF8 ACEF ADE2
Novel structural elements within the nonproteolytic clostridium botulinum type F toxin gene cluster.
Dover N, Barash JR, Hill KK, Detter JC, Arnon SS. (2011). Appl. Environ. Microbiol. PMID: 21183631. DOI: 10.1128/AEM.02422-10 BBID: F579
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.
Peng L, Tepp WH, Johnson EA, Dong M. (2011). PLoS Pathog. PMID: 21483489. DOI: 10.1371/journal.ppat.1002008 BBID: CE39
2010
Detection and differentiation of Clostridium botulinum type A strains using a focused DNA microarray.
Raphael BH, Joseph LA, McCroskey LM, Luquez C, Maslanka SE. (2010). Mol Cell Probes. PMID: 20056143. DOI: 10.1016/j.mcp.2009.12.003 BBID: BE12 ADF1 CF67 AC46
Further characterization of proteolytic Clostridium botulinum type A5 reveals that neurotoxin formation is unaffected by loss of the cntR (botR) promoter sigma factor binding site.
Carter AT, Mason DR, Grant KA, Franciosa G, Aureli P, Peck MW. (2010). J Clin Microbiol. PMID: 20042627. DOI: 10.1128/JCM.01774-09 BBID: 0147
Sequence diversity of genes encoding botulinum neurotoxin type F.
Raphael BH, Choudoir MJ, Luquez C, Fernandez R, Maslanka SE. (2010). Appl Environ Microbiol. PMID: 20511432. DOI: 10.1128/AEM.03109-09 BBID: DF19 CF09 A258 F579 E486 BD57 C237
Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding.
Stenmark P, Dong M, Dupuy J, Chapman ER, Stevens RC. (2010). J Mol Biol. PMID: 20219474. DOI: 10.1016/j.jmb.2010.02.041 BBID: AEF5
Structural analysis of botulinum neurotoxin type G receptor binding.
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Characterization of six type A strains of Clostridium botulinum that contain type B toxin gene sequences.
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Nucleotide sequence of Clostridium botulinum C1 neurotoxin.
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Nucleotide sequence of the gene encoding Clostridium botulinum neurotoxin type D.
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