BoNT/E3 (AD49)

Sequence

BLAST     FASTA    
MPKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTTPQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQHILLPNVIIMGAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSINEFIQDPALTLMHELIHSLHGLYGAKGITTTCIITQQQNPLITNRKGINIEEFLTFGGNDLNIITVAQYNDIYTNLLNDYRKIASKLSKVQVSNPQLNPYKDIFQEKYGLDKDASGIYSVNINKFDDILKKLYSFTEFDLATKFQVKCRETYIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIIKPITGRGLVKKIIRFCKNIVSVKGIRKSICIEINNGELFFVASENSYNDDNINTPKEIDDTVTSNNNYENDLDQVILNFNSESAPGLSDEKLNLTIQNDAYIPKYDSNGTSDIEQHDVNELNVFFYLDAQKVPEGENNVNLTSSIDTALLEQPKIYTFFSSEFINNVNKPVQAALFVSWIQQVLVDFTTEANQKSTVDKIADISIVVPYIGLALNIGNEAQKGNFKDALELLGAGILLEFEPELLIPTILVFTIKSFLGSSDNKNKVIKAINNALKERDEKWKEVYSFIVSNWMTKINTQFNKRKEQMYQALQNQVNAIKTIIESKYNSYTLEEKNELTNKYDIKQIENELNQKVSIAMNNIDRFLTESSISYLMKLINEVKINKLREYDENVKTYLLNYIIQHGSILGESQQELNSMVTDTLNNSIPFKLSSYTDDKILISYFNKFFKRIKSSSVLNMRYKNDKYVDTSGYDSNININGDVYKYPTNKNQFGIYNDKLSEVNISQNDYIIYDNKYKNFSISFWVRIPNYDNKIVNVNNEYTIINCMRDNNSGWKVSLNHNEIIWTLQDNAGINQKLAFNYGNANGISDYINKWIFVTITNDRLGDSKLYINGNLIDQKSILNLGNIHVSDNILFKIVNCSYTRYIGIRYFNIFDKELDETEIQTLYSNEPNTNILKDFWGNYLLYDKEYYLLNVLKPNNFIDRRKDSTLSINNIRSTILLANRLYSGIKVKIQRVNNSSTNDNLVRKNDQVYINFVASKTHLFPLYADTATTNKEKTIKISSSGNRFNQVVVMNSVGNNCTMNFKNNNGNNIGLLGFKADTVVASTWYYTHMRDHTNSNGCFWNFISEEHGWQEK

Properties

MW: 143,848.22 Da
No. of AA: 1252
Abs 0.1% (g/L): 1.155
pI: 5.99
NCBI ID: AFV91346.1
UniprotKB: A2I2S5
Strains: CB-K-39E, CDC59471, SOKR-23E1, VI9508E, CDC42861, MU8903E, CDC59470, IG0202E1, GL0410E1LC, MSKR5102E1, MU0103EMS, SOKR-43E2, SOKR-24E2, Lake Erie 4609, TRK02-06E2, NCTC 11219, FE0201E1BC, MI9608ESM, EK, RSKR-68E3, SOKR-22E1, F9508EPB, FWSK02-03E1, FE0211E1DK, MSKR5102E2, SOKR-43E1, FWKR02E1, TRK02-02E1, FE9708E1JI, FWSK02-01E3, SO325E1, GA0702E1CS, FE0005EJT, SOKR-27E3, Gordon, GA0202E1TS, CB-K-40E, IG0410E2LC, SOKR-24E1, SOKR-38E2, SOKR-38E3, SOKR-29E1, GA0108EJC, FE0202E1TC, GA9604ESM, Bennett, SWKR0402E1, INWB2202E1, CDC40329, SOKR-29E2, SO326E1, SOKR-25E2, IN01SE63E1, GA9811E1MS, GA0811E1IT, SOKR-38E1, TRK02-02E2, FE9709EBB, SOKR-27E1, K3, ME1010E1JL, SOKR-3602E1, MI9507E, FWSK02-06E2, GA9709EJA, F9508EMA, SOKR-50E2, CA9708E1, FE1010E1JL, FE9908EDL, SOKR-46E3, VI9608EPB, FWSKR4802E1, FE0801E1IT, VO0202E1TC, SO321E1, FWSK02-05E1, GA9604EAK, FE9604ENT, 11219, CDC59498, ME0702E1CS, GA1010E1JL, FWSK02-05E2, Abashiri, FE9507EEA, GA9709ENS, TRK02-04E3, FWSK02-01E2, FWSK02-07E2, Prevot R81-3A, SOKR-22E3, CB-K-45E, GA9811E2MS, SOKR-44E3, CB-K-44E, SOKR-14E1, SOKR-50E1, SO325E, FE9709ELB, V9804E, GA9608EPB, SP457-458E, BE9708E1, SOKR-23E3, FWSK02-04E1, SOKR-37E1, CB-K-38E, RSKR-68E1, FWSKR1302E1, Alaska E43, IG0201E2BC, GA0808EPA, CB-K-3E, SWKR0402E2, SOKR-35E3, S9510E, FWSK02-06E1, SOKR-35E1, SOKR-14E3, SOKR-20E1, Messaney, FWSK02-07E1, SOKR-24E3, TRK02-06E3, SOKR-25E3, FE9708E1PI, FE9909ERG, Foster B96, MU9708EJG-F235, FWSK02-02E1, MU0005EJT, SW279E, MI9706E, GA0702E1, SOKR-18E1, SWKR07E1, IG0410E3LC, SE9908E, FE9709ECB, IFR 18/104, ME0702E1CS*, E strain: K44, SOKR-44E3*, IFR 02/050, E strain: K117, SW279E*, E strain: K81, E strain: K3, AIP188.09
Associated Proteins: BoNT/E1 (D056).
Notes:

Associated Publications

Genetic diversity among Botulinum Neurotoxin-producing clostridial strains.
Hill KK, Smith TJ, Helma CH, Ticknor LO, Foley BT, Svensson RT, Brown JL, Johnson EA, Smith LA, Okinaka RT, Jackson PJ, Marks JD. (2007). J Bacteriol.
DOI: 10.1128/JB.01180-06   PMID: 17114256

Analysis of a unique Clostridium botulinum strain from the Southern hemisphere producing a novel type E botulinum neurotoxin subtype.
Raphael BH, Lautenschlager M, Kalb SR, de Jong LI, Frace M, Luquez C, Barr JR, Fernandez RA, Maslanka SE. (2012). BMC Microbiol.
DOI: 10.1186/1471-2180-12-245   PMID: 23113872

Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons.
Joussain C, Le Coz O, Pichugin A, Marconi P, Lim F, Sicurella M, Salonia A, Montorsi F, Wandosell F, Foster K, Giuliano F, Epstein AL, Aranda Muñoz A. (2019). Toxins (Basel)
DOI: 10.3390/toxins11020123   PMID: 30791373

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