BoNT/B4 (ACD0)

Sequence

BLAST     FASTA    
MPVTINNFNYNDPIDNDNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVEQKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDTIQAEELYTFGGQDPSIISPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFNKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKNMGKEYRGQNKAINKQAYEEISKEHLAVYKIQMCKSVKVPGICIDVDNENLFFIADKNSFSDDLSKNERVEYNTQNNYIGNGFPINELILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKVFTDENTIFQYLYSQTFPLNIRDISLTSSFDDALLVSSKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVDDFVIEANKSSTMDKIADISLIVPYIGLALNVGNETAKGNFESAFEIAGSSILLEFIPELLIPVVGVFLLESYIDNKNKIIKTIDNALTKRVEKWIDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYKYNIYSEEEKSNININFNDINSKLNEGINQAMDNINDFINECSVSYLMKKMIPLAVKKLLDFDNTLKKNLLNYIDENKLYLIGSVEDEKSKVDKYLKTIIPFDLSMYTNNEILIKIFNKYNSEILNNIILNLRYRDNNLIDLSGYGAKVEVYDGVKLNDKNQFKLTSSADSKIRVTQNQNIIFNSMFLDFSVSFWIRIPKYRNDDIQNYIHNEYTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNLDNAKIYINGTLESNMDIKDIGEVIINGEITFKLDGDVDRTQFIWMKYFSIFNTQLNQSNIKEIYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSYIKLVKDSSVGEMLIRSKYNQNSNYINYRNLYIGEKFIIRRKSNSQSINDDIVRKEDYIHLDFVNSNKEWRVYAYKNFKEQEQKLFLSIIYDSNEFYKTIQIKEYDEQPTYSCQLLFKKDEESTDEIGLIGIHRFYESGLLRKNYKDYFCISKWYLKEVKRKPYKSNLGCNWQFIPKDEGWTE

Properties

MW: 150,538.71 Da
No. of AA: 1291
Abs 0.1% (g/L): 1.295
pI: 5.47
NCBI ID: ABM73971
UniprotKB: A2I2R6
Strains: CDC5900, CDC 3897, 2129B, 5900 A-T-A-3, Hobbs FT50, ATCC 17844, CDC 3875, CDC3897, CDC 5900, CDC38597, H050880797, CDC3875, IFR 18/160, IFR 18/135, IFR 05/027, IFR 18/083, IFR 05/029, IFR 12/037, IFR 05/035, IFR 18/129, IFR 12/021, IFR 18/068, IFR 18/137, IFR 18/066, IFR 18/131, IFR 05/033, IFR 12/036, IFR 18/157, IFR 05/031, IFR 05/026, IFR 18/130, IFR 05/032, IFR_05/025, IFR 18/021, IFR 18/156, IFR 18/097, IFR 05/025, IFR 18/155, IFR 05/030, IFR 18/136, IFR 18/139, IFR 18/133
Associated Proteins: NTNH/B4 (B036). NTNH/B4 (4567).
Notes:

Associated Publications

Three classes of plasmid (47-63 kb) carry the type B neurotoxin gene cluster of group II Clostridium botulinum.
Carter AT, Austin JW, Weedmark KA, Corbett C, Peck MW. (2014). Genome Biol Evol.
DOI: 10.1093/gbe/evu164   PMID: 25079343

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.
Stern D, Weisemann J, Le Blanc A, von Berg L, Mahrhold S, Piesker J, Laue M, Luppa PB, Dorner MB, Dorner BG, Rummel A. (2018). PLoS Pathog.
DOI: 10.1371/journal.ppat.1007048   PMID: 29718991

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