BoNT/A2 (CEF8)

Sequence

BLAST     FASTA    
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFTGLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEEITADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGDSRIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEAFMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPALNIGNMLSKGEFVEAIIFTGVVAMLEFIPEYALPVFGTFAIVSYIANKVLTVQTINNALSKRNEKWDEVYKYTVTNWLAKVNTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINSAMININKFLDQCSVSYLMNSMIPYAVKRLKDFDASVRDVLLKYIYDNRGTLVLQVDRLKDEVNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVNTSILSIVYKKDDLIDLSRYGAKINIGDRVYYDSIDKNQIKLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNNEYTIINCIENNSGWKVSLNYGEIIWTLQDNKQNIQRVVFKYSQMVNISDYINRWIFVTITNNRLTKSKIYINGRLIDQKPISNLGNIHASNKIMFKLDGCRDPRRYIMIKYFNLFDKELNEKEIKDLYDSQSNSGILKDFWGNYLQYDKPYYMLNLFDPNKYVDVNNIGIRGYMYLKGPRGSVVTTNIYLNSTLYEGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFIGFHLYDNIAKLVASNWYNRQVGKASRTFGCSWEFIPVDDGWGESSL

Properties

MW: 149,411.88 Da
No. of AA: 1296
Abs 0.1% (g/L): 1.265
pI: 5.5
NCBI ID: WP_012703873.1
UniprotKB: Q45894
Strains: Af650, H094240742, CDC54095, H074240406, FRI-H1A2, CDC54063, H111880801g, CDC53123, AM282, CDC53120, CDC54065, CDC54069, 2G, H094160823, BrDuraAf, CDC54061, H094780541, Mauritius, H112480657, H112100518, Friedrichshain, H095040074, NCTC 9837, SU0635W, H094940215, Kyoto-F, H112060329, H093520263, CDC54070, SU1891, 224-13, Chiba-H, SU1074, SU0807, Af84, H094020617, CDC53126, CDC52353, SU1937, CDC54094, SU1887, SU1275, H111880801, H094500386, H111860974c, CDC 54084, CDC54071, H093760187, SU1064, CDC54056, CDC 54076, H094860240, SU0994, H093660254, SU1259, CDC53127, H093520024, H093320637, AM1051, CDC65104, Colworth BL237, H094460264, SU1112, H111860974g, 429-13, CDC53174, CDC 54093, SU1054, CDC54062, H093660253, SU1934, Kyoto, BrDura, CDC54057, 7I03-H, H093440416, SU1274, SU1304, SU0801, CDC54067, H093440236, CDC53125, CDC 54096, SU1306, H095200066, CDC 54091, SU0998, SU1072, H111860975g, CDC53119, SU1917, CDC57329, H094920429, CDC54055, CDC 49127, IFR 18/035, NCTC 9837 (2), F1904/97, IFR 12/040, IFR 18/039, IFR 18/036, IFR 15/031, F1413/94, AF84 (2), CDC_69094, IFR 18/031, IFR 16/385, IFR 16/622, IFR 18/032, CDC_53174, IFR 18/037, IFR 18/044, IFR 18/081
Associated Proteins: BoNT/B6 (BF38). NTNH/B6 (A568). BoNT/F4 (BD57). BoNT/F5 (CF09). BoNT/F4 (E567). NTNH/A2 (CF26). NTNH/A2 (BD27). BoNT/A1 (BE12).
Notes:

Associated Publications

Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
Dover N, Barash JR, Hill KK, Davenport KW, Teshima H, Xie G, Arnon SS. (2013). PLoS ONE
DOI: 10.1371/journal.pone.0061205   PMID: 23637798

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P. (2018). Toxins (Basel)
DOI: 10.3390/toxins10040153   PMID: 29649119

Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.
Benoit RM, Schärer MA, Wieser MM, Li X, Frey D, Kammerer RA. (2017). Sci Rep
DOI: 10.1038/srep43588   PMID: 28252640

Comparison of efficacy and toxicity between botulinum toxin subtypes A1 and A2 in cynomolgus macaques.
Torii Y, Sasaki M, Shin MC, Akaike N, Kaji R. (2018). Toxicon
DOI: 10.1016/j.toxicon.2018.08.017   PMID: 30193802

Persistence of botulinum neurotoxin a subtypes 1-5 in primary rat spinal cord cells.
Whitemarsh RC, Tepp WH, Johnson EA, Pellett S. (2014). PLoS ONE
DOI: 10.1371/journal.pone.0090252   PMID: 24587301

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